The Prophet-5 is an analog synthesizer manufactured by the American company Sequential. It was designed by Dave Smith and John Bowen in 1977, who used microprocessors, then a new technology, to create the first polyphonic synthesizer with fully programmable memory. This allowed users to store sounds and recall them instantly rather than having to reprogram them manually; whereas synthesizers had once created unpredictable sounds, the Prophet-5 moved synthesizers to producing "a standard package of familiar sounds".^: 385

Between 1978 and 1984, about 6,000 units were produced across three revisions. In 1981, Sequential released a 10-voice, double-keyboard version, the Prophet-10. Sequential introduced new versions in 2020, and it has been emulated in software synthesizers and hardware. The Prophet-5 has been widely used in popular music and film soundtracks.